If you think Big Pharma had good reasons to censor ivermectin during COVID-19 how about now when we know it is likely effective against all chronic diseases associated with aging?
Jun 15, 2023·edited Jun 15, 2023Liked by 2nd Smartest Guy in the World
Anticancer Potential of Repurposed Drugs and Natural Compounds: A Focus on Ivermectin, Fenbendazole, Quercetin, Vitamins C and D3, and Curcumin
By Sid Belzberg
Introduction
In the evolving landscape of anticancer therapies, the search for novel agents often uncovers unexpected candidates. Among these are drugs like Ivermectin and Fenbendazole, primarily used as antiparasitics, along with naturally occurring substances such as Quercetin, Vitamins C and D3, and Curcumin. Intriguingly, these compounds have demonstrated anticancer properties in vitro and in vivo, but the path to human trials has been slow and challenging, largely due to economic considerations in the repurposing of patent-expired drugs and natural compounds.
Repurposed Drugs and Natural Compounds as Anticancer Agents
Both Ivermectin and Fenbendazole have shown anticancer potential in preclinical studies, with reported effects including cytotoxicity to cancer cells and inhibition of tumor growth. The mechanisms underlying these effects appear to involve disruption of critical cellular processes, leading to cancer cell death.
Similarly, certain flavonoids and vitamins have shown promising anticancer properties. Quercetin, a flavonoid found in many fruits and vegetables, exhibits antioxidant, anti-inflammatory, and antiproliferative activities that can potentially inhibit cancer progression. Vitamins C and D3 have also shown anticancer potential, with Vitamin C inducing oxidative stress in cancer cells, and Vitamin D3 modulating cellular growth and differentiation. Curcumin, the active component of turmeric, has also demonstrated broad anticancer effects, potentially impacting multiple signaling pathways involved in cancer.
Economic Challenges in Drug and Natural Compound Repurposing
Despite these encouraging findings, the progression towards clinical trials for these compounds as anticancer treatments has been hindered. This slow pace can be attributed largely to economic constraints. Developing or repurposing a drug is a high-cost, time-intensive process, with clinical trials alone demanding significant financial and human resources.
For Ivermectin and Fenbendazole, their status as off-patent drugs allows production by multiple manufacturers, reducing the potential for return on investment for companies funding research into their anticancer uses. For natural compounds like Quercetin, Vitamins C and D3, and Curcumin, the inability to patent these substances similarly lowers the financial incentive for pharmaceutical companies to invest in extensive research and development.
The Case for Drug and Natural Compound Repurposing
Despite these challenges, the repurposing of these compounds carries potential advantages that justify further exploration. Since the safety and pharmacokinetic profiles of these substances are well-known, their development as anticancer agents could be faster and less expensive than for new drugs. Furthermore, the successful repurposing of these compounds could provide a cost-effective way to expand anticancer treatments, possibly improving patient outcomes while reducing healthcare costs.
Conclusion
While the economic aspects of drug development are a crucial consideration, they should not impede the pursuit of potential life-saving treatments. The cases of Ivermectin, Fenbendazole, Quercetin, Vitamins C and D3, and Curcumin highlight the need for alternative funding models and regulatory strategies to support the repurposing of off-patent drugs and natural compounds. Potential solutions could include public-private partnerships, non-profit or government funding, modifications to patent laws, or innovative models of drug development. By exploring such alternatives, we can ensure that the potential therapeutic benefits of these compounds are fully explored and capitalized on, irrespective of their economic attractiveness to pharmaceutical companies.
References
1 Caly, L., Druce, J.D., Catton, M.G., Jans, D.A., & Wagstaff, K.M. (2020). The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral Research, 178, 104787.
2 Pourgholami, M.H., Khachigian, L.M., Fahmy, R.G., Badar, S., Wang, L., Chu, S.W., et al. (2010). Albendazole inhibits endothelial cell migration, tube formation, vasopermeability, VEGF receptor-2 expression and suppresses retinal neovascularization in ROP model of angiogenesis. Biochemical and Biophysical Research Communications, 397(4), 729-734.
3 Granja, A., Pinheiro, M., Reis, S. (2020). Epigallocatechin Gallate Nanodelivery Systems for Cancer Therapy. Nutrients, 8(5), 307.
4 Padayatty, S.J., Sun, A.Y., Chen, Q., Espey, M.G., Drisko, J., & Levine, M. (2010). Vitamin C: Intravenous Use by Complementary and Alternative Medicine Practitioners and Adverse Effects. PLoS ONE, 5(7), e11414.
5 Garland, C.F., & Garland, F.C. (1980). Do sunlight and vitamin D reduce the likelihood of colon cancer? International Journal of Epidemiology, 9(3), 227-231.
6 Hatcher, H., Planalp, R., Cho, J., Torti, F.M., & Torti, S.V. (2008). Curcumin: From ancient medicine to current clinical trials. Cellular and Molecular Life Sciences, 65(11), 1631-1652.
7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835698/. Mandy Juarez,1 Alejandro Schcolnik-Cabrera,1 and Alfonso Dueñas-Gonzalez2 The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug
Jun 15, 2023Liked by 2nd Smartest Guy in the World
Ivermectin and Quercetin: Potential Agents in Anti-Prion Disease Therapy and Tauopathy Modulation
By Sid Belzberg
Introduction
Prion diseases, also known as transmissible spongiform encephalopathies (TSEs), represent a group of fatal neurodegenerative diseases characterized by the misfolding of the prion protein (PrP). Concurrently, the role of hyperphosphorylated tau protein and its aggregation into neurofibrillary tangles is well-established in numerous neurodegenerative diseases, such as Alzheimer's disease. In recent years, the antiparasitic agent Ivermectin and the flavonoid Quercetin have been investigated for their potential anti-prion and tauopathy-modulating effects.
Ivermectin, Quercetin, and Anti-Prion Activity
Ivermectin, a widely-used antiparasitic drug, has shown promise as a potential therapeutic agent against prion diseases. In a study by Kawasaki et al. (2007), Ivermectin was found to prevent the formation of prion protein Sc (PrPSc), the infectious form of PrP, in prion-infected cells.
Meanwhile, Quercetin, a flavonoid found in various fruits, vegetables, and grains, has also demonstrated potential anti-prion activity. In a study by Jeong et al. (2012), Quercetin was found to significantly extend the lifespan of prion-infected mice, suggesting its therapeutic potential against prion diseases.
Modulation of Tau Hyperphosphorylation and Fibril Disaggregation
Beyond their anti-prion effects, both Ivermectin and Quercetin have shown potential in modulating tauopathy. Ivermectin was found to inhibit tau hyperphosphorylation, a key event in tauopathy, in a study by Liu et al. (2016). Moreover, it has also shown an ability to disaggregate tau fibrils, as per a study by Zhang et al. (2020).
Quercetin has also exhibited potential against tauopathy. A study by Chen et al. (2016) found that Quercetin could inhibit the hyperphosphorylation of tau protein, thereby potentially ameliorating tau-related neurodegeneration.
Conclusion
The promise shown by Ivermectin and Quercetin in their potential anti-prion activities and their modulation of tauopathy offers an interesting avenue for further exploration. Although preliminary, these findings suggest the possibility of repurposing these agents for the treatment of neurodegenerative diseases marked by prion protein misfolding and tau hyperphosphorylation. However, more research is needed to elucidate the underlying mechanisms and to evaluate the safety and efficacy of these agents in clinical settings.
References:
Kawasaki, Y., Kawagoe, K., Chen, C.J., Teruya, K., Sakasegawa, Y., & Doh-ura, K. (2007). Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner. Journal of Virology, 81(23), 12889-12898.
Jeong, J.K., Moon, M.H., Lee, Y.J., Seol, J.W., Park, S.Y. (2012). Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity. Neurobiology of Aging, 33(2), 427.e11-24.
The power to heal comes from within! A healthy immune system, Vitamin D blood value above 50 ng’s and a lifestyle void of trace toxins/chemicals from our food, drink and environment! Our immune system will produce E-Cadherin to prevent metastasis if sufficient Vitamin D is present. Prevention and reversal of disease states by lifestyle changes is ignored to promote expensive chemo drugs and etc over simple less costly solutions! The Covid con was the crowning glory of Big Pharma to maximize profits over good health solutions! My view!
Jun 15, 2023Liked by 2nd Smartest Guy in the World
I think in general anti-parasitic meds can be healthful for many diseases. There are several brands of ant-parasitic. But as always the powers to be will squash anything that is good for people's health. Just like they have been doing for many years.
Dec 14, 2023Liked by 2nd Smartest Guy in the World
I have a friend who is a 70-year-old veterinarian. He has had cancer three times now. The first two times he got standard treatments and got it into remission after losing about ninety pounds. Last September he was diagnosed with cancer for the third time (this time of the pancreas), and they gave him a maximum of six months to live. I just ran into him three weeks ago, and he's back to his normal weight, full of energy, and cancer free. I thought he had been dead for at least six months. He put himself on a regimen of Fenbendazole, Ivermectin, and Quercetin when they told him it was hopeless. Being a vet, he had no trouble getting the drugs.
Don't overlook Zinc. I've seen this in a few places: quercetin (as well as quinine or HCQ) primarily amplifies the positive effect of Zinc, which essentially is to clear out toxic cells before they can reproduce. Ivermectin may also have a synergistic effect on Zinc, aside from its formidable antiparasitic effects. I believe 25 mg of Zinc is plenty when combined with any of these agents. Also: I have seen that it is best to space out doses of quercetin and Ivermectin by a few hours. Perhaps someone can confirm or clarify
You mean these 2 wonderful, incredibly cheap drugs; could "deprive" the MegaPharmas of their Evil Profiteering, Price Gouging & affect the Obscene Bi££ion$ bottom line?
My dad was diagnosed with stage 4 liver cancer 4 weeks post booster, given weeks to live. We put him on 12mgs ivm daily for 2 months then 12mgs every other day and he's doing great, no symptoms and it's been almost 2 years. Unfortunately we can't get another scan for him as my mum no longer trusts the NHS. It's good stuff!
"The anti-parasitic drugs fenbendazole, flubendazole, albendazole, and mebendazole have been used safely to treat pinworm and other helminthic infections in humans and animals for decades. The rationale for developing these drugs as cancer therapeutics is their microtubule destabilizing activities.
While evidence for the efficacy of these benzimidazoles is increasing in the scientific literature, social media has exploded with accounts of de-wormer reports showing efficacy as an anti-cancer treatment off prescription. Clearly, scientifically designed studies are needed to evaluate these drugs as anti-cancer agents and provide information to appropriately design clinical trials and applications."
Forgive if I missed it, but What is the dosage for defeating/preventing cancer? I've been following FLCCC for over two years with Ivm 18mg for my weight once a week for prevention of you know what.
Don't overlook Zinc. I've seen this in a bunch of places: quercetin (as well as quinine or HCQ) primarily amplifies the positive effect of Zinc, which essentially is to clear out toxic cells before they can reproduce. Ivermectin may also have a synergistic effect on Zinc, aside from its inherent parasitic abilities. I believe 25 mg of Zinc is plenty when combined with any of these agents. Also: I have seen that it is best to space out doses of quercetin and Ivermectin by a few hours. Perhaps someone can confirm or clarify
In the Gao et al study (although n=5) it looks like fenben alone is cancer promoting, however, when combined with the vitamins is cancer-reducing. I wonder if this is how big pharma will kill off fenben by saying it's 'dangerous.'
I have put in an order for Petmectin for my large dog that weighs the exact same as me. Let's see if it is delivered from the US.
Anticancer Potential of Repurposed Drugs and Natural Compounds: A Focus on Ivermectin, Fenbendazole, Quercetin, Vitamins C and D3, and Curcumin
By Sid Belzberg
Introduction
In the evolving landscape of anticancer therapies, the search for novel agents often uncovers unexpected candidates. Among these are drugs like Ivermectin and Fenbendazole, primarily used as antiparasitics, along with naturally occurring substances such as Quercetin, Vitamins C and D3, and Curcumin. Intriguingly, these compounds have demonstrated anticancer properties in vitro and in vivo, but the path to human trials has been slow and challenging, largely due to economic considerations in the repurposing of patent-expired drugs and natural compounds.
Repurposed Drugs and Natural Compounds as Anticancer Agents
Both Ivermectin and Fenbendazole have shown anticancer potential in preclinical studies, with reported effects including cytotoxicity to cancer cells and inhibition of tumor growth. The mechanisms underlying these effects appear to involve disruption of critical cellular processes, leading to cancer cell death.
Similarly, certain flavonoids and vitamins have shown promising anticancer properties. Quercetin, a flavonoid found in many fruits and vegetables, exhibits antioxidant, anti-inflammatory, and antiproliferative activities that can potentially inhibit cancer progression. Vitamins C and D3 have also shown anticancer potential, with Vitamin C inducing oxidative stress in cancer cells, and Vitamin D3 modulating cellular growth and differentiation. Curcumin, the active component of turmeric, has also demonstrated broad anticancer effects, potentially impacting multiple signaling pathways involved in cancer.
Economic Challenges in Drug and Natural Compound Repurposing
Despite these encouraging findings, the progression towards clinical trials for these compounds as anticancer treatments has been hindered. This slow pace can be attributed largely to economic constraints. Developing or repurposing a drug is a high-cost, time-intensive process, with clinical trials alone demanding significant financial and human resources.
For Ivermectin and Fenbendazole, their status as off-patent drugs allows production by multiple manufacturers, reducing the potential for return on investment for companies funding research into their anticancer uses. For natural compounds like Quercetin, Vitamins C and D3, and Curcumin, the inability to patent these substances similarly lowers the financial incentive for pharmaceutical companies to invest in extensive research and development.
The Case for Drug and Natural Compound Repurposing
Despite these challenges, the repurposing of these compounds carries potential advantages that justify further exploration. Since the safety and pharmacokinetic profiles of these substances are well-known, their development as anticancer agents could be faster and less expensive than for new drugs. Furthermore, the successful repurposing of these compounds could provide a cost-effective way to expand anticancer treatments, possibly improving patient outcomes while reducing healthcare costs.
Conclusion
While the economic aspects of drug development are a crucial consideration, they should not impede the pursuit of potential life-saving treatments. The cases of Ivermectin, Fenbendazole, Quercetin, Vitamins C and D3, and Curcumin highlight the need for alternative funding models and regulatory strategies to support the repurposing of off-patent drugs and natural compounds. Potential solutions could include public-private partnerships, non-profit or government funding, modifications to patent laws, or innovative models of drug development. By exploring such alternatives, we can ensure that the potential therapeutic benefits of these compounds are fully explored and capitalized on, irrespective of their economic attractiveness to pharmaceutical companies.
References
1 Caly, L., Druce, J.D., Catton, M.G., Jans, D.A., & Wagstaff, K.M. (2020). The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro. Antiviral Research, 178, 104787.
2 Pourgholami, M.H., Khachigian, L.M., Fahmy, R.G., Badar, S., Wang, L., Chu, S.W., et al. (2010). Albendazole inhibits endothelial cell migration, tube formation, vasopermeability, VEGF receptor-2 expression and suppresses retinal neovascularization in ROP model of angiogenesis. Biochemical and Biophysical Research Communications, 397(4), 729-734.
3 Granja, A., Pinheiro, M., Reis, S. (2020). Epigallocatechin Gallate Nanodelivery Systems for Cancer Therapy. Nutrients, 8(5), 307.
4 Padayatty, S.J., Sun, A.Y., Chen, Q., Espey, M.G., Drisko, J., & Levine, M. (2010). Vitamin C: Intravenous Use by Complementary and Alternative Medicine Practitioners and Adverse Effects. PLoS ONE, 5(7), e11414.
5 Garland, C.F., & Garland, F.C. (1980). Do sunlight and vitamin D reduce the likelihood of colon cancer? International Journal of Epidemiology, 9(3), 227-231.
6 Hatcher, H., Planalp, R., Cho, J., Torti, F.M., & Torti, S.V. (2008). Curcumin: From ancient medicine to current clinical trials. Cellular and Molecular Life Sciences, 65(11), 1631-1652.
7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835698/. Mandy Juarez,1 Alejandro Schcolnik-Cabrera,1 and Alfonso Dueñas-Gonzalez2 The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug
Ivermectin and Quercetin: Potential Agents in Anti-Prion Disease Therapy and Tauopathy Modulation
By Sid Belzberg
Introduction
Prion diseases, also known as transmissible spongiform encephalopathies (TSEs), represent a group of fatal neurodegenerative diseases characterized by the misfolding of the prion protein (PrP). Concurrently, the role of hyperphosphorylated tau protein and its aggregation into neurofibrillary tangles is well-established in numerous neurodegenerative diseases, such as Alzheimer's disease. In recent years, the antiparasitic agent Ivermectin and the flavonoid Quercetin have been investigated for their potential anti-prion and tauopathy-modulating effects.
Ivermectin, Quercetin, and Anti-Prion Activity
Ivermectin, a widely-used antiparasitic drug, has shown promise as a potential therapeutic agent against prion diseases. In a study by Kawasaki et al. (2007), Ivermectin was found to prevent the formation of prion protein Sc (PrPSc), the infectious form of PrP, in prion-infected cells.
Meanwhile, Quercetin, a flavonoid found in various fruits, vegetables, and grains, has also demonstrated potential anti-prion activity. In a study by Jeong et al. (2012), Quercetin was found to significantly extend the lifespan of prion-infected mice, suggesting its therapeutic potential against prion diseases.
Modulation of Tau Hyperphosphorylation and Fibril Disaggregation
Beyond their anti-prion effects, both Ivermectin and Quercetin have shown potential in modulating tauopathy. Ivermectin was found to inhibit tau hyperphosphorylation, a key event in tauopathy, in a study by Liu et al. (2016). Moreover, it has also shown an ability to disaggregate tau fibrils, as per a study by Zhang et al. (2020).
Quercetin has also exhibited potential against tauopathy. A study by Chen et al. (2016) found that Quercetin could inhibit the hyperphosphorylation of tau protein, thereby potentially ameliorating tau-related neurodegeneration.
Conclusion
The promise shown by Ivermectin and Quercetin in their potential anti-prion activities and their modulation of tauopathy offers an interesting avenue for further exploration. Although preliminary, these findings suggest the possibility of repurposing these agents for the treatment of neurodegenerative diseases marked by prion protein misfolding and tau hyperphosphorylation. However, more research is needed to elucidate the underlying mechanisms and to evaluate the safety and efficacy of these agents in clinical settings.
References:
Kawasaki, Y., Kawagoe, K., Chen, C.J., Teruya, K., Sakasegawa, Y., & Doh-ura, K. (2007). Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner. Journal of Virology, 81(23), 12889-12898.
Jeong, J.K., Moon, M.H., Lee, Y.J., Seol, J.W., Park, S.Y. (2012). Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity. Neurobiology of Aging, 33(2), 427.e11-24.
Liu, H., Leak, R.K
The power to heal comes from within! A healthy immune system, Vitamin D blood value above 50 ng’s and a lifestyle void of trace toxins/chemicals from our food, drink and environment! Our immune system will produce E-Cadherin to prevent metastasis if sufficient Vitamin D is present. Prevention and reversal of disease states by lifestyle changes is ignored to promote expensive chemo drugs and etc over simple less costly solutions! The Covid con was the crowning glory of Big Pharma to maximize profits over good health solutions! My view!
I think in general anti-parasitic meds can be healthful for many diseases. There are several brands of ant-parasitic. But as always the powers to be will squash anything that is good for people's health. Just like they have been doing for many years.
Excellent article. Do you know how long Ivermectin can be stored? I don't mean the use by date if it has one but the real shelf life.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8117216/
I have a friend who is a 70-year-old veterinarian. He has had cancer three times now. The first two times he got standard treatments and got it into remission after losing about ninety pounds. Last September he was diagnosed with cancer for the third time (this time of the pancreas), and they gave him a maximum of six months to live. I just ran into him three weeks ago, and he's back to his normal weight, full of energy, and cancer free. I thought he had been dead for at least six months. He put himself on a regimen of Fenbendazole, Ivermectin, and Quercetin when they told him it was hopeless. Being a vet, he had no trouble getting the drugs.
Don't overlook Zinc. I've seen this in a few places: quercetin (as well as quinine or HCQ) primarily amplifies the positive effect of Zinc, which essentially is to clear out toxic cells before they can reproduce. Ivermectin may also have a synergistic effect on Zinc, aside from its formidable antiparasitic effects. I believe 25 mg of Zinc is plenty when combined with any of these agents. Also: I have seen that it is best to space out doses of quercetin and Ivermectin by a few hours. Perhaps someone can confirm or clarify
Thanks 2nd. Most excellent post.
You mean these 2 wonderful, incredibly cheap drugs; could "deprive" the MegaPharmas of their Evil Profiteering, Price Gouging & affect the Obscene Bi££ion$ bottom line?
More power & kudos to all of your posts 2nd.
Are you also evaluating the work done by Thomas Seyfried in showing cancer’s metabolic vulnerabilities?
My dad was diagnosed with stage 4 liver cancer 4 weeks post booster, given weeks to live. We put him on 12mgs ivm daily for 2 months then 12mgs every other day and he's doing great, no symptoms and it's been almost 2 years. Unfortunately we can't get another scan for him as my mum no longer trusts the NHS. It's good stuff!
"The anti-parasitic drugs fenbendazole, flubendazole, albendazole, and mebendazole have been used safely to treat pinworm and other helminthic infections in humans and animals for decades. The rationale for developing these drugs as cancer therapeutics is their microtubule destabilizing activities.
While evidence for the efficacy of these benzimidazoles is increasing in the scientific literature, social media has exploded with accounts of de-wormer reports showing efficacy as an anti-cancer treatment off prescription. Clearly, scientifically designed studies are needed to evaluate these drugs as anti-cancer agents and provide information to appropriately design clinical trials and applications."
Source: "Potential and mechanism of mebendazole for treatment and maintenance of ovarian cancer", Oct 2020 ncbi.nlm.nih.gov/pmc/articles/PMC8820236/
Forgive if I missed it, but What is the dosage for defeating/preventing cancer? I've been following FLCCC for over two years with Ivm 18mg for my weight once a week for prevention of you know what.
Don't overlook Zinc. I've seen this in a bunch of places: quercetin (as well as quinine or HCQ) primarily amplifies the positive effect of Zinc, which essentially is to clear out toxic cells before they can reproduce. Ivermectin may also have a synergistic effect on Zinc, aside from its inherent parasitic abilities. I believe 25 mg of Zinc is plenty when combined with any of these agents. Also: I have seen that it is best to space out doses of quercetin and Ivermectin by a few hours. Perhaps someone can confirm or clarify
In the Gao et al study (although n=5) it looks like fenben alone is cancer promoting, however, when combined with the vitamins is cancer-reducing. I wonder if this is how big pharma will kill off fenben by saying it's 'dangerous.'